What is the difference between Smooth Endoplasmic Reticulum and Rough Endoplasmic Reticulum?

Smooth Endoplasmic Reticulum:-

1. SER is not associated with ribosomes.

2. These are mainly composed of tubules.

3. Generally, these are associated with plasma membrane.

4. Main function is lipid synthesis and hence mostly seen in cells associated with synthesis of steroid hormones.

Rough Endoplasmic Reticulum:-

1. RER is studded with ribosomes.

2. These are mainly composed of cisternae.

3. Generally associated with nuclear membrane.

4. Main function is protein synthesis and hence mostly seen in cells associated with secretion of proteins.