Following entry of the toxic agent into the blood stream its localisation is dependent on the blood flow, the permeability of the tissues to the toxic agents and immediate availability of the binding sites.
With time more binding sites may be available while the pattern of blood flow may also vary and these factors acting cumulatively redistribute the toxic agent in the body of the organisms.
A familiar example of redistribution of toxic agent is, again that of lead which immediately after absorption is localised in the erythrocytes, liver and kidney – in the liver alone almost 50% of the total lead can be found within an hour or two after its administration. In about a month’s time most of the lead, almost 90% occurs in bones.