We have already mentioned the progress made in the field of metallurgy. The machines of early historical India were simple devises such as the variyantra, a kind of water spray for cooling the air.

The presence of Yavana engineers in Kushana court and in the Tamil literature shows interaction in this field. Engineering skills in the building of dams and irrigation tanks are evident from their remains.

Geometry seems to have developed and was increasingly being used in erecting fire altars. In the field of astronomy, the Greek influence is evident from the text Romaka Siddhanta. The seven days division of a week and the names of satellites are Roman borrowings. The Indo-Greeks seem to have introduced the tradition of putting images of kings and engraving legends on the coins.

Indian medicine made remarkable progress during this period. The surgical equipments in common consisted of twenty-five types of knives and needles, thirty probes, twenty tabular instruments and twenty-six articles of dressing. Charaka wrote Charakasamhita. He stayed at the court of Kanishka. The Greek botanist Theophrastus gives details of the medicinal plants and herbs from India in his History of Plants.