Here are your brief notes on Mould Lubricant

Mould lubricants are used to remove theobroma suppositories without damaging their surfaces unless a lubricant is used. Lubrication is essential for glycero-gelatin bases because of their sticky nature. Following lubricants may be used for the preparation of theobroma oil suppositories.

Lubricant must be compatible with medicament or adjuncts. In industry silicone fluid is used as lubricant. Mould is lubricated using a pad of gauze or muslin or with a small fairly stiff brush.

Cotton wool is not used because some fibers adhere to the mould. Excess of lubricant can be removed by inverting the mould on a clean white tile.

Example 1: Prepare and dispense Compound Bismuth Subgallate Suppositories.

Bismuth subgallate 200.0 mg

Resorcinol 60.0 mg

Zinc oxide 120.0 mg

Castor oil 60.0 mg

Theobroma oil, sufficient to fill a mould

Method of Dispensing:

Melt theobroma oil and add other additives and mix uniformly properly lubricate the suppository mould and pour the hot base in the moulds and cod immediately in ice bath.

Excess of substance is scrapped off and re-used in next lot. Open the mould and remove the suppository carefully. Pack in butter paper and store in a well-closed container.

Uses: Astringent and antacid

Example 2: Prepare and dispense Glycerol Suppositories.

Rx

Gelatin 14.0 g

Glycerol 70.0 g

Purified water, sufficient to produce 100.0 g

Method of Dispensing:

Soak gelatin in purified water for about five minutes or until thoroughly softened. Drain well and add glycerin and heat on water bath.

Evaporate excess quantity until the mixture weighs 100 g. Pour the products into suitable moulds.

Uses : Rectal evacuant.

Example 3: Prepare and dispense Glycerin Suppositories

Rx

Glycerin 91.0 g

Sodium stearate 9.00 g

Purified water 5.00 g

Method of Dispensing:

Heat the weighed amount of glycerin in a suitable container to about 120°C. Sodium stearate is dissolved in the heated glycerin with stirring. Add purified water and mix. Pour the hot mixture in the suitable mould.

Uses: Local application

Example 4: Prepare and dispense Glycerinated Gelatin Suppositories.

Drug and purified water 10.0 g

Gelatin 20.0 g

Glycerin 70.0 g

Method of Dispensing:

Dissolve the drug in purified water and moisten the gelatin. Heat the glycerin and add gelatin and drug solution. Mix uniformly and pour this mixture in a mould.

Uses: Antimicrobial.

Example 5: Prepare and dispense Tannic Acid Suppositories.

Rx

Tannic acid 0.2 g

Theobroma oil, sufficient to produce qs

Method of Dispensing:

Add lubricant in the mould and remove the excess of lubricant by draining and cool the lubricated mould over ice. Theobroma oil is heated in a porcelain dish over a water bath and avoid over heating. Remove dish from the water bath as soon as the mass is molten.

Weighed amount of tannic acid is powdered and added in the molten theobroma oil. Mix the tannic acid by spatula (sometimes molten theobroma oil divided in two parts) and pour the mixture into the holes in the moulds. Place the mould on ice and remove excess mass carefully by sharp knife.

When the suppositories have completely set hard, open the mould and remove the suppositories by slight pressure on the broad ends. Remove any lubricant on final product, by rolling on the filter papers.

Uses: Astringent