Here is your short essay on Nasal Sprays

Sprays are solutions of various drugs in aqueous vehicles and are applied to the mucous membrane of the nose and the throat by means of an atomizer or nebulizer.

Spray devices should produce relatively coarse droplets if the therapeutic action of the medicaments is to be restricted to the upper respiratory tract. Very fine droplets penetrate into the respiratory tract.

Initially the sprays were prepared by dissolving various medicaments in light liquid petrolatum. It may damage the normal ciliary activity of the nasal mucosa and, if drops of oil enter the trachea it can cause lipoid pneumonia. Because of this problem, aqueous sprays that are isotonic with nasal secretions and of approximately the same pH are preferred.

Sprays contain substances such as antibiotics, antihistamines, vasoconstrictors, alcohol, solubilizers, and wetting agents.

Example 01: Prepare and dispense Isoprenaline Compound Spray.

Isoprenaline

Papaverine hydrochloride

Atropine methonitrate

Propylene glycol

Sodium metabisulphite

Purified water, sufficient to produce

Method of Dispensing:

Mix isoprenaline, atropine methonitrate and papaverine hydrochloride and dissolve in purified water. Dissolve sodium metabisulphite and add in the solution. Add other additives and add sufficient purified water to produce 25 ml.