It was after the conquest of Kabul that Babur turned his wistful eyes to India. He laid the foundation of the Mughal rule in India in 1526 by defeating Ibrahim Lodi, the last of the Turco-Afghan rulers, in the first battle of Panipat (1526).
Firstly, the importance of the first battle of Panipat lies in the fact that it made the beginning of the Mughal rule in India. Secondly, the victory in the battle made Babur the master of Delhi and Agra, the two political centers of northern India.
Thirdly, the treasures that Babur came to acquire from the royal treasury of Delhi made him financially very strong. Fourthly the battle of Panipath ushered in a new chapter of Mughal-Afghan contest.
Fifthly, the first battle of Panipat opened the gate for Mughal-Afghan contest that continued even after the death of Babur. Sixthly, as pointed out by Satish Chandra the real importance of the first battle of Panipath lies in the fact that it opened a new phase in the struggle for domination in North India.