As a result of the Battle of Kanwah, the power of the Rajputs was crippled, but no crushed. Babur marched against Chanderi which was a stronghold of the Rajputs under Medini Rai. This Rajput Chief was very powerful and had made his position felt in Malwa. Babur reached Chanderi on 20th January, 1528. The Mughals besieged the Fort where Medini Rai had taken shelter with his 5,000 followers.
Medini Rai refused to enter into any treaty with Babur and also did not accept Babur’s offer of a Jagir in lieu of Chanderi. Consequently, Babur pressed the siege of Chanderi with full vigour and attacked the Fort of Chanderi from all sides. The Rajputs were determined to fight to the finish and their women burnt themselves by performing Jauhar. Almost all the Rajputs lost their lives. On 29th January, 1528, the Fort of Chanderi was captured. After this no other Rajput chief could challenge the authority of Babur.