Transient hypogammaglobulinemia of infancy is a form of hypo-gamma-globulinemia that appears after birth and results in reduction in the IgG level and sometimes IgA and IgM also.

Normally by three months of age babies’ start synthesizing their own antibodies, as their maternal antibodies wane, but in transient hypogammagloubulinaemia the onset of normal immunoglobulin synthesis is delayed for as long as 36 months until then such infants are susceptible to pyogenic infections.