There are several types of B cell defects that lead to “hypogammaglobulinemia”. Sever reduction in antibodies is a characteristic feature of hypogammaglobulinemia syndrome.

This immune deficiency is an outcome of both inherited and developmental disorders.

The common defects associated with B-cell function are:

a) X-linked agammagloubulin anemia

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b) IgA deficiency

c) IgG sub class deficiency

d) Immuno deficiency with increased IgM

e) Common variable immuno deficiency

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f) Transient hypo gammaglobulin anemia of infancy.