1. An elevated level of immunoglobulins.

2. Demonstrable levels of auto antibodies.

3. Deposition of immunoglobulins or their derivatives at the site of trouble such as renal glomeruli.

4. Accumulation of lymphocytes and plasma cells at the site of lesions.

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5. Temporary or lasting benefit from immunosuppressive therapy.

6. Occurrence of more than one type of autoimmune lesion in an individual.

7. Genetic predisposition towards autoimmunity.