Papaya mosaic disease is caused by papaya ring spot virus, which occurs in all aerial parts of host except the seeds. The disease appears as profuse mottling and puckering of young leaves and subsequently developing ones. Symptoms more conspicuous than mosaic are reduced size, chlorotic and malformed appearance of young leaves. Defoliation of older leaves results in presence of tuft of small leaves at the top. Infected plants show degeneration and marked reduction in growth. As the virus is transmitted by aphids, spray of insecticides to keep the vectors away to reduce the incidence of disease.