The only achievement of Soares in South India was a treaty with Quilon whereby the Portuguese secured some favourable trade facilities. The queen of Quilon was trying from the time of Cabral to open negotiations with the Portuguese for establishing trade connection with them. During Almeda’s time a Portuguese factory was opened there but soon it was pulled down by the mob who suffered at their hands.

Albuquerque tried to mend the rupture and the queen of Quilon, disregarding the warning given by the Zamorin, went more than half the way to accommodate him and a treaty was concluded. Local opposition fomented by Muslims created difficulties for the Portuguese but Lopo Soares surmounted these by some fresh concessions from the ruler and permission to erect a fort at Quilon. Christians also got some impetus as he wrested the right of conversion for the Christians.

However, the Portuguese had an uneasy and unstable existence in Quilon, Cochin and Calicut, mostly on account of their religious aggrandisement and high-handedness in commercial activities. Reintroduction of private trade by Soares which Albuquerque suppressed with a heavy hand made the Portuguese unscrupulous and greedy which told upon their fortune in South India.