Notes on the Safety Cover of Pharmaceutical Products

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Notes on the Safety Cover of Pharmaceutical Products . PVC sleeves, which slide over either the packaging, closure or in some cases the whole package. Shrink bands make products tamper evident increasing the safety of product.

Shrink bands:

PVC sleeves, which slide over either the packaging, closure or in some cases the whole package. Shrink bands make products tamper evident increasing the safety of product.

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Induction sealing:

A specialized laminate containing an aluminum foil and a plastic heat sealable film which hermetically seals a container through the use of a cap sealing machine.

Child-resistant caps (CR caps):

A closure requiring dissimilar motions making removal by a child difficult. Child Resistant closures are subject to current Government Regulations.

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Material for Construction of Closures

Cork: It is obtained from the bark of a certain variety of oak growing in Mediterranean countries. It is used in the manufacturing of stoppers for glass bottles. Cork is almost inert and does not impart any undesirable odour to product.

Glass :

As compared to cork, glass stoppers are more elegant but unless properly ground, they may allow leakage. The use of glass closures is mainly restricted to laboratory glassware in pharmaceutical field.

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Metals :

In modern dispensing, metal closures are very common. They are made from aluminium and tin plate.

Plastics :

Cork, glass and metal closures have been mostly replaced by plastic and metal closures with liners of cork or other resilient materials. They can be easily molded to various shapes and sizes easily. Plastics selected for stoppers should particularly be tested for any extractive matter present in them and for their reaction with contents of the containers.

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Rubber :

Natural rubber imparts a characteristic odor to product. Synthetic rubbers like silicone, neoprene, nitrile or butyl are expensive. Rubber closures are commonly used for vials of antibiotics and multidose injectable.

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